Steroids and derivatives
Medchemexpress LLC Dexamethasone palmitate | 14899-36-6 | 99.7% | 50 MG
Dexamethasone palmitate (DXP) is a prodrug of Dexamethasone, primarily utilized in inflammation research. It has demonstrated in vitro anti-inflammatory effects by decreasing LPS-induced MCP-1 and TNF-α concentrations in RAW 264.7 cells. In vivo studies in New Zealand White rabbits have shown that Dexamethasone palmitate, administered via IVT injection, distributes significantly in the vitreous humor and can control VEGF-induced vascular hyperpermeability.
- Appearance: Solid, white to off-white
- Purity: 99.68%
- Molecular weight: 630.87
- Formula: C38H59FO6
- Primarily for inflammation research
- Demonstrates in vitro anti-inflammatory effects (decreases LPS-induced MCP-1 and TNF-α)
- In vivo studies show significant distribution in vitreous humor and control of VEGF-induced vascular hyperpermeability
Medchemexpress LLC Hydrocortisone hemisuccinate hydrate | 83784-20-7 | 96.42% | 25 MG
Hydrocortisone hemisuccinate hydrate is a glucocorticoid and an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. It inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. This compound is suitable for use in the study of ulcerative colitis (UC) and recurrent oral ulcers.
- Glucocorticoid
- Orally active steroidal anti-inflammatory agent
- Inhibits IL-6 and IL-3 bioactivity
- Used in ulcerative colitis research
- Used in recurrent oral ulcers research
Medchemexpress LLC Prednisone | 53-03-2 | 99.8% | 25 MG
Prednisone is an analytical standard and a corticosteroid agent with anti-inflammatory and immunosuppressive effects. It is intended for research and analytical applications, particularly for studying diseases like systemic lupus erythematosus. This reference standard is suitable for qualitative, quantitative, and methodological research experiments using techniques such as HPLC, GC, and MS.
- Analytical standard for research
- Corticosteroid agent with anti-inflammatory effects
- Immunosuppressive properties
- Useful for studying systemic lupus erythematosus
- Compatible with HPLC, GC, and MS research experiments
Medchemexpress LLC Dexamethasone phosphate disodium | 2392-39-4 | 99.9% | 1 G
Dexamethasone phosphate disodium is an orally active Glucocorticoid receptor agonist.
- Orally active Glucocorticoid receptor agonist.
- Soluble in water (≥ 100 mg/mL).
- Soluble in DMSO (1 mg/mL).
- Cited in 15 publications, with 8 specifically using this product.
Medchemexpress LLC Hydrocortisone sodium phosphate | 6000-74-4 | MFCD00152562 | 99.1% | 486.40 g·mol⁻¹ | C21H29Na2O8P | 100 MG
Hydrocortisone sodium phosphate is the sodium phosphate ester of hydrocortisone, a short-acting glucocorticoid corticosteroid supplied as a white to off-white solid. Its water-soluble form is suitable for biochemical, pharmacological, and formulation studies where a soluble corticosteroid derivative is required.
- High purity: 99.1%.
- Water soluble for easy formulation and in vitro use.
- Molecular weight 486.40 g·mol⁻¹.
- White to off-white solid appearance.
- Provided in small pack sizes suitable for laboratory research.
Medchemexpress LLC Hydrocortisone acepo 25mg | 74050-20-7 | 460.56 g/mol | C26H36O7 | 25 MG
Hydrocortisone aceponate is supplied as an analytical standard for laboratory research into topical glucocorticoid activity. It is provided as a small solid pack appropriate for in vitro and analytical assays, with reported high purity and defined molecular properties.
- Purity listed as 97% for reliable analytical use.
- Molecular formula C26H36O7 and molecular weight 460.56 g/mol for accurate calculations.
- CAS number 74050-20-7 for unambiguous compound identification.
- Available in small pack sizes suitable for method development and standards preparation.
- Intended application: analytical and research use for dermal glucocorticoid studies.
Medchemexpress LLC Dexamethasone palmitate-d31 | 14899-36-6 | 99.3% | 2.5 MG
Dexamethasone palmitate-d31 is an isotope-labeled compound, specifically a deuterium-labeled version of Dexamethasone palmitate, which is a proagent of Dexamethasone. This compound is primarily utilized in research contexts, particularly for studies related to inflammation.
- Can be used as a tracer.
- Serves as an internal standard for quantitative analysis.
- Compatible with analytical techniques such as NMR, GC-MS, and LC-MS.
Medchemexpress LLC Hydrocortisone acepo 25mg | 74050-20-7 | 460.6 g/mol | C26H36O7 | 25 MG
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate, CAS 74050-20-7) is a topical glucocorticoid research compound used to study anti-inflammatory and antipruritic effects in dermatological and veterinary settings. It is supplied for formulation, pharmacology, and analytical research, typically as a high-purity solid suitable for analytical standards and small-scale formulation work.
- Topical glucocorticoid with anti-inflammatory and antipruritic activity.
- Suitable for dermatological and veterinary research applications.
- Supplied as a research-grade solid, typically ≥98% purity.
- Available in small analytical/package sizes, e.g., 25 MG, for formulation and assay work.
- Soluble in common organic solvents such as chloroform and methanol for analytical preparation.
Medchemexpress LLC 21-deoxy cortisone | 1882-82-2 | MFCD00051123 | 344.44 | C21H28O4 | 5mg
21-Deoxy Cortisone (21-Desoxycortisone NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone It is formed from 11-ketoprogesterone by the cytochrome P450 (CYP) isozyme CYP17A1 but can also be produced by oxidation of 21-deoxycortisone (HY-113405) by 11 -hydroxysteroid dehydrogenase type 2 (11 -HSD2) Congenital adrenal hyperplasia is an inborn error of metabolism characterized by a deficiency of 21-hydroxylase and 21-Deoxy Cortisone levels are elevated in patients with congenital adrenal hyperplasia
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | MFCD00083363 | 486.64 | 20 MG
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, intended for research use only. It demonstrates diverse biological activities in vitro.
- Shows dose-dependent down-regulation of GR transcript in hCMEC/D3 cells and significantly increases TER across the hCMEC/D3 monolayer.
- Decreases expression of MHC II molecules, costimulatory molecule CD86, and DC-specific marker CD83 in treated dendritic cells, along with strongly reduced IL-12 secretion.
- Inhibits IFN-γ production but induces increased IL-4 release in dendritic cells.
- Reduces postischemic oxidative stress, perfusion pressure, transudate formation.
- Inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as histamine release from mast cells.
Sigma Aldrich Fine Chemicals Biosciences Hydrocortisone Impurity D100MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC Hydrocortisone acepo 5mg | 74050-20-7 | 460.56 g·mol⁻¹ | C26H36O7 | 5 MG
Hydrocortisone aceponate is supplied as an analytical standard of hydrocortisone 17-propionate 21-acetate for research and analytical applications, commonly used as a reference in assay development and dermatoses studies.
- Analytical standard of hydrocortisone aceponate for research and assays.
- Declared purity suitable for HPLC analysis (97%).
- Molecular formula C26H36O7 and molecular weight 460.56 g·mol⁻¹.
- Supplied in a small 5 mg quantity for analytical use.
- Suitable as a reference standard in topical glucocorticoid research.
Medchemexpress LLC 17-hydroxy-11-dehydrocorticosterone | 53-06-5 | 99.3% | 360.44 | 5 G
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is an oxidized metabolite of Cortisol, a Glucocorticoid. It functions as an immunosuppressant and anti-inflammatory agent. At high concentrations, Cortisone can partially interfere with the binding of Glucocorticoid to the Glucocorticoid-receptor. This product is intended for research use only.
- Oxidized metabolite of Cortisol
- Functions as an immunosuppressant
- Acts as an anti-inflammatory agent
- Partially interferes with Glucocorticoid-receptor binding
- For research use only
Medchemexpress LLC Dexamethasone phosphate disodium | 2392-39-4 | 99.9% | 1 ML
Dexamethasone phosphate disodium is an orally active Glucocorticoid receptor agonist. It regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM.
- Induces transcription of the β2-receptor (EC50=36 nM).
- Inhibits 3xκB (NF-κB, IκBα, and I-κBβ) with IC50=0.5 nM.
- Effectively inhibits lipopolysaccharide (LPS)-induced inflammation.
- Decreases recruitment of granulocytes and spontaneous production of oxygen radicals.